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Home Azerbaijan Technologies 1,3-Dimethyl-6-(2-Oxyethyl)-7-OXO-1,2-Dihydropyrrol [3,4-C] Pyridine Showing Neurotropic Activity

1,3-Dimethyl-6-(2-Oxyethyl)-7-OXO-1,2-Dihydropyrrol [3,4-C] Pyridine Showing Neurotropic Activity


It is elaborated the method of preparation of 1,3-dimethyl- 6-(2-oxyethyl)-7-oxo-1,2-dihydropyrrol [3,4-c] pyridine by interaction of 4,5-dichloro-3-penten-2-one with ethyl ether of 2,6-dimethyl of β-aminocrotonic acid with the subsequent treatment of the prepared intermediate product with monoethanolamine.

Innovative Aspect and Main Advantages

Simplification of process due to exception of purification and isolation of intermediate ethyl ether of 2,6-dimethyl-4- chlormethylnicotinic acid and also use of water instead of organic solvents. In introduction of 1,3-dimethyl-6-(2- oxyethyl)-7-oxo-1,2-dihydropyrrol[3,4]pyridine into outbred white mice intraperitoneally in 40mg/kg dose exceeds a neurotropic activity of sodium salicylate widely used in medical practice. It is referred to practically non toxic compounds (LD56=486 mg/kg).

Areas of Application

It can be applied in medicine as neurotropic drug and also in thin organic synthesis for preparation of 6-[2-chloro - methylcarbonyl (2-dialkylaminomethylcarbonyl) ethoxy -7- oxo-1,2-dihydropyrrolo[3,4-c]pyridines.

Fig. 1 1,3-Dimethyl-6-(2-oxyethyl)-7-oxo-1,2-dihydro-pyrrol [3,4-c]pyridine.

Stage of Development

Laboratory tested on white mice. Inv. Certificate USSR has been received.

Contact Details

Institute of Polymer Materials
Contact persons: Gadzhili R.A.
Address: 124, S.Vurgun St. AZ5004, Sumgait, Azerbaijan
Tel: (+994 55) 706 1613; (+994 18) 644 6645; (+994 18) 642 2124
Fax: (+994 18) 642 0400
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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