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Home Azerbaijan Technologies 1-(2-Oxyethyl)-2-Methylpyrrole for Biologically Active Anticoagulant, Hypotensive, Fibrinolytic Preparations

1-(2-Oxyethyl)-2-Methylpyrrole for Biologically Active Anticoagulant, Hypotensive, Fibrinolytic Preparations

Description

It has been developed one-stage and preparative method of preparation of 1-(2-oxyethyl)-2-methylpyrrole with 73% yield by the interaction of 4,5-dichloropentan-2-one with monoethanolamine in the presence of acceptor of hydrogen chloride.

Innovative Aspect and Main Advantages

Simplification of process due to exception of purification and isolation of intermediate 5-chlor-3-penten-2-one. 1-(2- Oxyethyl)-2-methylpyrrole contains in its molecule highly reactive oxyethyl group, therefore on its base new structural analogs of natural biologically active compounds can be synthesized. The known analog is prepared in 2 stages with 45-50% yields.

Areas of Application

It can be applied in thin organic synthesis for preparation of potentially biologically active anticoagulant, hypotensive, fibrinolytic and other substances.


Fig. 1 1-(2-Oxyethyl)-2-methylpyrrole.

Stage of Development

Laboratory tested technology.

Contact Details

Institute of Polymer Materials
Contact persons: Gadzhili R.A.
Address: 124, S.Vurgun St. AZ5004, Sumgait, Azerbaijan
Tel: (+994 55) 706 1613; (+994 18) 644 6645; (+994 18) 642 2124
Fax: (+994 18) 642 0400
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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