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Home Azerbaijan Technologies 1-Benzyl-2-Methylpyrrole Showing Antimicrobial Activity

1-Benzyl-2-Methylpyrrole Showing Antimicrobial Activity


It is developed one-stage method of preparation of 1-benzyl- 2-methylpyrrole with 72% yield by interaction of 4,5- dichloropentan-2-one with benzylamine in the presence of acceptor of hydrogen chloride.

Innovative Aspect and Main Advantages

Simplification of process due to exception of purification and isolation of intermediate 5-chloro-3-penten-2-one. 1- Benzyl-2-methylpyrrole at minimum suppresses concentration (MSC) 125 mkg/ml possesses expressed antimicrobial activity against Escherichia coli and Pseudomonas aeruginosa and also against serration and at MSC 250 mkg/ml – against fungi Candida. By the efficiency the compound considerably exceeds nitrofungin and chloramine used in medical practice. It is referred to low toxic compounds (LD50=360 mg/kg).

Areas of Application

It can be applied in medicine as antimicrobial drug.

Fig. 1 1-Benzyl-2-methylpyrrole.

Stage of Development

Laboratory tested technology.

Contact Details

Institute of Polymer Materials
Contact persons: Gadzhili R.A.
Address: 124, S.Vurgun St. AZ5004, Sumgait, Azerbaijan
Tel: (+994 55) 706 1613; (+994 18) 644 6645; (+994 18) 642 2124
Fax: (+994 18) 642 0400
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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