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Home Azerbaijan Technologies 3-Methyl-5-Bromomethylisoxazole Showing Pronounced Antimicrobial Activity

3-Methyl-5-Bromomethylisoxazole Showing Pronounced Antimicrobial Activity


It is developed the regioselective method of preparation of 3-methyl-5-chloromethylisoxazole by interaction of 5,4- dichlor-3-penten-2-one with hydroxylamine with the subsequent treatment of the prepared 3-methyl-5-chloromethylisoxazole with potassium bromide.

Innovative Aspect and Main Advantages

Novelty is the regioselective direction of reaction to the way of formation of 3-methyl-5-chloromethylisoxazole. The compounds in minimal suppressed concentration 50 mkg/ml completely prevent a growth of salmonella cultures, colon and blue pus bacilli, goldish staphylococcus and Candida albicans.

Areas of Application

It can be used in veterinary practice and also in thin organic synthesis for preparation of 5-alkoxy(aryloxy)methyl-, 5-dialkylaminomethyl-, 5-R-aminomethylisoxazoles.

Fig. 1 3-Methyl-5-bromomethylizoxazole.

Stage of Development

Laboratory tested.

Contact Details

Institute of Polymer Materials
Contact persons: Gadzhili R.A.
Address: 124, S.Vurgun St. AZ5004, Sumgait, Azerbaijan
Tel: (+994 55) 706 1613; (+994 18) 644 6645; (+994 18) 642 2124
Fax: (+994 18) 642 0400
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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