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Home Azerbaijan Technologies Ethyl Ether of 2,6-Dimethyl-4-Morpholinomethylnicotinic Acid Showing Antihypoxic and Antiaggregant Activity

Ethyl Ether of 2,6-Dimethyl-4-Morpholinomethylnicotinic Acid Showing Antihypoxic and Antiaggregant Activity

Description

It is developed the one-stage method of preparation of ethyl ether of 2,6-dimethyl-4-morpholinomethylnicotinic acid by interaction of 4,5-dichloro-3-penten-2-one with ethyl ether of β-aminocrotonic acid with the subsequent treatment of prepared intermediate by morpholine.

Innovative Aspect and Main Advantages

Simplification of process due to exception of purification and isolation of intermediate ethyl ether of 2,6-dimethyl-4- chlormethylnicotinic acid. Ethyl ether of 2,6-dimethyl-4- morpholinomethylnicotinic acid in 1,5-2 times is effective than piracetam widely using in medical practice as antihypoxic preparation, its antiagregant activity in 2-3 times is higher than of aspirin and terental. It is referred to practically low-toxic compounds LD50=240 (148-300 mg/kg).

Areas of Application

It can be used in medicine as antihypoxic and antiaggregant means and also for preparation of amide and salts of 4-morpholinomethylnicotinic acid.


Fig. 1 Ethyl ether of 2,6-dimethyl-4-morpholinomethylnicotinic acid.

Stage of Development

The solid medical form of derivative of nicotinic acid which is referred to non toxic compounds (LD50=650 mg/kg) has been prepared and laboratory tested on animals. Inv. Certificate USSR is received.

Contact Details

Institute of Polymer Materials
Contact persons: Gadzhili R.A.
Address: 124, S.Vurgun St. AZ5004, Sumgait, Azerbaijan
Tel: (+994 55) 706 1613; (+994 18) 644 6645; (+994 18) 642 2124
Fax: (+994 18) 642 0400
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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