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Home Azerbaijan Technologies 1-Methoxycarbinolmethyl-2-Methylpyrrole Showing Adaptogenic Activity

1-Methoxycarbinolmethyl-2-Methylpyrrole Showing Adaptogenic Activity

Description

It is developed the method of preparation of structural analogue of natural biologically active ether of 2-pyrrol carboxylic acids - 1-metoxycarbonylmetyhl-2-methylpyrrole by interaction of 5- chlor-3-penten-2one with hydrochloride of methyl ether of aminoacetic acid in the presence of acceptor of hydrogen chloride.

Innovative Aspect and Main Advantages

In introduction of compound into white mice subcutaneously in a dose of 0,2 and 1,0 mg/kg an endurance of animals at functional overloading in comparison with mice to which were entered infusion of eleutherococcus at the same doses increased more than 2 times. An introduction of compound in doses of 0,1 and 1,0 mg/kg favors increase of longevity of animals in insufficiency of oxygen, and in excess of carbonic gas on air for 20-24% is more in comparison with infusion eleutherococcus. It is referred to non toxic compounds LD50=2319(1610-3320) mg/kg.

Areas of Application

It can be used as adaptogenic means, and also in thin organic synthesis for preparation of amides, hydrazides, salts and other pyrrole derivatives.


Fig. 1 1-metoxycarbonylmethyl-2-methylpyrrole.

Stage of Development

Laboratory tested on white mice. Inv. Certificate USSR has been received.

Contact Details

Institute of Polymer Materials
Contact persons: Gadzhili R.A.
Address: 124, S.Vurgun St. AZ5004, Sumgait, Azerbaijan
Tel: (+994 55) 706 1613; (+994 18) 644 6645; (+994 18) 642 2124
Fax: (+994 18) 642 0400
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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