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Home Biotechnologies Personal UV Biodosimeters VITA-D

Personal UV Biodosimeters VITA-D.

Technical Description

Personal biodosimeter VITA-D is designed to measure the vitamin-D-synthetic capacity of sunlight and/or artificial ultraviolet radiation in-situ. using the same photochemical process from which vitamin D3 is synthesized in human skin. Polymer films doped with molecules of 7-dehydrocholesterol (Provitamin D3) are used as photo-sensing elements. This film is an analogue of human skin due to its property to synthesize Provitamin D under ultraviolet radiation.

The transmission coefficient of this film in the spectral range which corresponds to one of the absorption bands (-280 nm) in the provitamin D spectrum is dependent on the amount of synthesized provitamin D molecules. The specific 'antirachitic' UV biodose can be calculated from the change of the film transmission measured before and after a sunlight exposure using a calibration chart that establishes a relationship between the transmission change and the accepted UV dose.

Personal biodosimeter is a portable instrument that measures the transmission coefficient of specialized polymer films doped with provitamin D3 in a narrow range of wavelengths - 280 nm. The photosensitive film is inserted into the receiving chamber of the device, where the UV light from LED is allowed to pass through the film is received by a photodiode, which reading is digitized and stored in the memory of microprocessor. To increase the accuracy, the averaging method is used, where the number of consecutive measurements (from 2 to 20) is pre-set. The device can store the results of 2000 values along with metadata (date and time). These data can be displayed on the LCD screen or transferred to a computer via USB port. The software developed ans built-in in the device allows to control and observe graphically the dynamics of accumulation of the received dose and to calculate the amount of vitamin D synthesized.

Basic Operational Principle

Special polymer films and/or cholesteric liquid crystals are doped with molecules of pro-vitamin D and are used as bio-analogue photo-registering elements. In the first case the dose measurement is based on changes in the transmission coefficient properties of the film and in the second case it is based on the shift of the reflection band of wave length.

VITA-D: Personal UV Biodosimeter
VITA-D: Personal UV Biodosimeter.

Technical Specifications

  • Size of the photosensitive film.........................................1cm x 2cm
  • Size of the irradiated surface...........................................5 x 5 mm
  • Dynamic range of the dose characteristics of the film........0-1000 J/m2
  • Controled Waveband transmission...................................280±10nm
  • Measurement error.........................................................0.4m/cm2
  • Number of stored measurements.....................................2,000
  • Voltage consumed.........................................................+9V
  • Battery life without recharging.........................................38 hours
  • Unit dimensions............................................................18cm x 5cm x 3cm
  • Unit weight...................................................................400 g

Novelty Features

The personal biodosimeter series VITA-D are designed to measure in-situ and directly the vitamin D-synthetic capacity of UV radiation both of sunlight and of artificial origin. Use of bio equivalence technologies, makes them superior to all other UV Biodosimeters in the marketplace as they generate measurements based upon the same molecular photochemistry by which Vitamin D is photosynthesized in human skin. Therefore, direct and reliable measurements of provitamin D formation, can be taken in-situ and read "on- the-spot".

Enhanced Applications

Personal biodosimeters Vita-Dare versatile, portable and affordable instruments that can be used by health professionals, operators and users of tanning equipment and health-conscious individuals. A host of other applications can be envisaged. To name a few, reptile care, mushroom growth, tanning and skin protection, protective cream industries etc.

UV radiation and human skin: cause of serious concerns and undeniable benefits.

During the recent decades, because of the ozone destruction phenomenon, Ultra-Violet Radiation type B (280-315nm) is increasingly monitored and screened as the undesirable cause of erythema- sunburn, premature aging of skin and even skin cancer. But all that may occur at upon excess UV exposure-doses.

But natural exposure to the sunlight is undeniably responsible for the "in-taking" of 90% of our the Vitamin D and -as it proves in our days-this "sunny" vitamin is much more important and indispensable to the human body, as it controls almost 2.000 out of our 10.000 human genes. Its mineralization effect in relation to bone health proves today to expand well beyond our skeleton (see the diagram below).


Biologically active UVB radiation , initiates photo-chemically through the human skin. A Vitamin D synthesis process that ends-up deeper through the liver to the kidneys to get its ultimate activated form. The VITA-D Biodosimeter's bioequivalence technology, enables the alerted user to quit with the risky application of arbitrary rules of thumb for sun exposure, and enables him to determination e more precisely the appropriate sunlight dose that makes him harvest the sun's benefits while avoiding its threats.

Vitamin D3 (cholecalciferol) does not have significant biological activity by itself and must be metabolized within the body to the hormonally-active form.

This transformation occurs in two steps:

  • Within the liver, cholecalciferol is hydroxylated to 25-hy-droxycholecalciferol by the enzyme 25-hydroxylase.
  • Within the kidney, 25-vitamin D serves as a substrate for 1-alpha-hydroxylase, yielding 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D.


Fig. A


Fig. B

Fig. A shows the change in the absorption spectrum of provitamin D in a polymer film as a result of UV irradiation with fluorescent EL-30 lamp for 100 minutes.

Fig. B shows the dependence of the absorbance measured at a 280 nm wavelength (vertical axis) on the received UV doses (horizontal axis).


Fig. C

Fig. C shows cross-correlation dependence between absorbance change (vertical axis) and provitamin D concentration (horizontal axis).

Contact Details

Prof. Irina Terenetskaya
(+38 044) 525 0813
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Technology Transfer Office
Organization: Institute of Physics, NASU
Adress: 46, Nauky Avenue, 03680, Kyiv, Ukraine
(+38 044) 525 9841
Fax: (+38 044)525 1589
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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