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Home Biotechnologies Development of the Novel Bioceramic Implants for Complete Bone Restoration

Development of the Novel Bioceramic Implants for Complete Bone Restoration

Description

The bioactive ceramics are the only synthetic materials that are not perceived by an organism as foreign body and have the potential to ensure full bone tissue restoration, considerably improve local drug delivery systems and numerous other medical technologies. But their practical application often leads to contradictory results.

Our main idea is that to achieve the best results the ceramics must meet a number of biological demands depending on kind of operation and the patient's condition. The comprehensive analysis of a number surgery applications of different bioactive ceramics implants, about 700 surgeries with experimental animals, biochemical study of immune and blood characteristics of patients and animals, as well as long experience of synthesis and modification of numerous bioactive ceramics went us to the conclusion that the main way to ensure the best results of bone tissue remodelling is usage of bioactive ceramic composites with adjustable biological and surgery properties. The developed composites consist of modified HAP, HAP-TCP compositions, different bioglasses and glass-ceramics. This concept have been applied in bone tumor and trauma surgery, cranial surgery, otorhinolaryngology, dentistry and maxillofacial surgery. The proposed conception permitted us to obtain outstanding results in all listed branches of surgery and serves as the base for further developments. Some results of applications of the developed materials and implants made of them are presented in this report.


Bone defects remain intact
for months without filling.


Filling defects with the composite
results in full bone restoration.


Biotransformation of the composite
(white) into bone (pink)

Innovative Aspect and Main Advantages

The innovative aspect of proposed technology consists in regulation of the biocomposites' biotransformation process, elimination of usage of autogenous bone for bone plastic (which lead to incurable trauma and add twice the surgery complexity). Special kind of the bioactive ceramic composite has the property of shrinkageless ceramic mass and has been developed to produce individual ceramic implants based on 3D models obtained by X-ray tomography for cranial and other branches of surgery. This material is also innovative.

For example, the surgery of non-cancerous and malignant bones tumor result in large bone defects - up to 100 cm3 and more. Therefore the actual problem is selection of bone-plastic materials that ensure the best bone tissue remodeling. The presented data summarize the outcomes of bone-plastic surgery operations made to 172 patients due to giant cell myeloma and noncancerous bone tumors, made during last 7 years. For filling bone defects one of two kinds of synthetic bone-plastic materials have been utilized: stoichiometric nanohydroxyapatite (HAP) and bioceramic composite consisting of several kinds of modificated bioactive glasses and glass-ceramics and two-phase HAP-TCP nanopowder. To control remodeling processes and to prevent tumor relapses the biopsies were taken in different terms (2-9 months) after surgeries. The study was made by electron microscope.


Result of operation for forehead restoration
with the biocomposite.


Fitting of the biocompositc implant at
the skull model

Summarizing the obtained outcomes allows to single out the common features of bone tissue remodelling for both utilized materials: activation of phagocytosis of tissue detritus by macrophages, proliferation of vascular endothelium and osteoblasts, active generating of bone tissue islands through classic stages of random collagen osteoid formation with transition to ordered osteogenesis, absence of implants' immune and inflammation tearing away. The specific features of these processes at bioceramic composite applications: reduced lymphahistocyte infiltration, considerable decreasing of fibrous connective tissue quantity in the place of implantation, higher rate and degree of resorption of the implant, higher rate of collagen osteoid formation followed by its ossificatiom and creation of bone islands around and instead of implant's fragments, greater density of created bone and its resistance to lead-acid decalcification, smooth and more quick healing of the bone defect.

Areas of Application

All kinds of surgery operations with bone tissue: orthopaedics (bone trauma and tumor surgery), cranial surgery, otorhinolaryngology, dentistry and maxillofacial surgery.


Bone plastic with the biocomposite granules after bone tumour surgery.

Stage of Development

We have Health Ministry Certificate for clinical usage of the biocomposite for 5 years now and accumulated experience more than thousand of surgery operations. This permit us to improve further the properties of the composite and to study the multifunctional application of the developed composites.


Statistics of hospital stay after otolaryngology
operations with the biocomposite.


Orthopaedics screws with the biocomposite coatings.

Contact Details

Vitalii A.Dubok.
Frantsevich Institute for Problems of Materials Science of NASU.
Address: 3, Krzhizhanovski str., Kyiv.
+380(44)4247256, +380(44)4242024
E-mail This e-mail address is being protected from spambots. You need JavaScript enabled to view it .

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