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Home Biotechnologies Biomaterials for Bone Surgery

Biomaterials for Bone Surgery


Production of a ceramic hydroxylapatite, biphase material on a basis tricalcium phosphate (TCP) and HAP and only TCP, in a form of fine dispersed a powder, granules with various dispersions, ceramic porous wedges, porous and dense cylinders, blocks and individual products of the various form is proposed.

Examples of various kinds of production
Examples of various kinds of production

The investigations are conducted together with leading Institutes of National Academy of Science of Ukraine and Academy of Medical Sciences of Ukraine to be interested in development of new technologies of osteotropic materials production, study of their structure, morphology, physical-chemical and mechanical properties, and also toxicological, morphological and hystological research of interaction of developed materials with a bone tissue. Materials with various defects in structure are created. Methods for creation of paramagnetic markers in structure of HAP and TCP and TCP are developed.

Mechanisms of interaction and replacement of a material by a bone tissue are studied, and also quality of regenerated tissue with the help of entered markers in structure of an apatite is investigated. Influence of parameters on the synthesis to such properties of a material, as a resorbtion degree, osteoconduction, rate of replacement is investigated. Experiments on the animals with the subsequent hysto-morphological research of regeneration have carried out in leading Institute of orthopeady and traumatology in Medical University of Ukraine.

During the study of sites bone and gristle tissue, which are situated around the ceramics, the tissues on distance from implants and rests of a ceramic material, taken together during regeneration, traditional methods of research (X-ray diffraction, IRS, electronic microscopy), and new methods for this application (EPR, NMR) were used. Biochemical research with the purpose of revealing influence of implants on a mineral exchange, and also influences on general somatical status of the animals, have shown, that the long presence implants in an organism does not result in essential changes metabolitic status of the experimental animals.

The materials on the basis of HAP and TCP permitted to application are widely applied in clinics as bone implants. Significant experience of use of various kinds of a material in different clinical cases is collected.

Main advantages of proposed materials are the following:

  • High biological compatibility.
  • Absence of immune and inflammatory response on an organism to a material.
  • Absence of fibrous tissue encapsulation of the implants.
  • Implant integration with bone tissue by formation of a bone - ceramic composite.
  • Acceleration of reparation processes in a bone tissue.
  • A gradual substitution of the implants by a high-grade bone tissue.

Application of implants:

  • Bone defects plastic surgery at tumor or like tumor diseases of a bone.
  • Planimetric plastic and replacement operating and traumatic of defects at fracture of the bottom jaw.
  • Replacement of sites of the bottom jaw (more than 1/3).
  • Osteoporosis - for restoration of structure of a bone tissue.
  • Treatment of the paradontite and periodontite.
  • Restoration of the alveolar ring.
  • Filling of root channels with taking out of a material for a top of a tooth.
  • Filling of defects, formed in result of removal of periapical areas of odontogenic infection (granulemes, kistes) at simultaneous preservation of causing teeth (with resection of a top of tooth root).
  • Acceleration of biologisation of metal implants.
  • Treatment hypersensitivity of neck of a tooth.
  • Filling of places after removal of teeth.
  • Radical hymorotimia concerning hymorite with punching of according places.
  • Fulfillment of corrigirate osteomia with use of figure implants.
  • Escalating a bone by strong connection of a implant surface with a bone without formation of fibrous capsule between them.

Together with ceramic HAP and TCP development new biocompatible materials with improved mechanical properties on the base of glassceramic are investigated.

The basic distinctive peculiarity of these implants consists in formation the direct biochemical connection between implants and bone owing to occurrence on a surface of hydroxylapatite implants layer, which is strongly connected to a hydroxyapatite of a bone.

Application of such implants will allow to combine the advantages of osteotropic ceramics with a hydroxyapatite, which forms direct connection with a bone, but has insufficient durability, with high durability and split characteristics of glassceramics. Using of glassceramics allows also to apply rather simple technology of implant manufacturing of the complex form by casting on scuttled models in special formation weight.

In connection with arising interest to covering on titanium implants by powders of TCP and HAP, glassceramic which have the stable structure at high temperatures and low resorbtion degree and forming easy dissolution active phases are developed. The methods of properties research of coverings and mechanism of its interaction with a bone tissue are developed.

Contact Details

Nataliya Ulyanchich
Frantsevich Institute for Problems of Materials Science of NASU.
Address: 3, Krzhizhanovski str., Kyiv.
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it .

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