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Home Biotechnologies Instrument for blindness treatment caused by the age related macula degeneration

Instrument for blindness treatment caused by the age related macula degeneration

Description

Vascular disorders in retina are very common causes of severe and often irreversible loss of vision. In age-related macula degeneration (AMD), abnormal blood vessels grow beneath the macula – the central part of the retina. They leak and bleed, causing disturbance of central vision. Later, the light-sensitive retinal cells (photoreceptors) degenerate, and scar tissue grows in the macula. This causes a blind spot in the center of vision.

Current treatments for vascular disorders in retina include laser surgery and laser therapy to eliminate the crucial influence of abnormal blood vessels. Sophisticated laser-based technologies are in use today: laser photocoagulation, photodynamic therapy (PDT), and transpupillary laser thermotherapy (TTT). Unfortunately, none of them can solve the problem of adequate dosage of the irradiation, that is an extremely critical matter.

The Institute of Biomedical Engineering of the Academy of Technological Sciences of Ukraine has developed several technologies, enabling multichannel online control of the procedure of the transpupillary thermotherapy, based on the changes of the topography of the eye bottom, and on the level and dynamics of blood flow as well as its oxygenation during tissue heating.

Temperature difference between treated and untreated zones achieves 10°C and more. The growth of temperature of the irradiated tissue leads to dimension changes, and thus to the changes of the topography of the eye bottom. We use the phase-difference dualbeam interferometry where the reference beam is kept in a reference position without scanning. A second, frequency-shifted beam is scanned along a trajectory,crossing the treated and untreated zones of the eye bottom (V. Molebny. Proc. SPIE, Vol. 5086, 2003). Changes in phase structure are analyzed to have an estimate on thermal processes in the retina. On eye model, sensitivity to profile variation of the order of 0.1 μm has been achieved.

The blood flow is controlled through the Doppler shift measurement. Level of blood oxygenation and its dynamics is controlled by a specially developed technology of multispectral infrared sensing which excludes eye media backscattered light.

Zone of control: reference (red) and scanning (blue) beams
Fig. 1 Zone of control: reference (red) and
scanning (blue) beams


Fig. 2 Normalized height across the scanned area for two
positions of the retina model: a - initial position;
b - shifted 5 μm forward


Fig. 3 Optical layout

Stage of Development

Medical research

Contact Details

Prof. Molebny V. V.
Tel: (380 68) 364-4969
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Mrs. Zheltovska T. V.
Tel: (380 44) 526-5443
Academy of Technological Sciences of Ukraine
42, Acad. Glushkov Prospect, 03187 Kiev, Ukraine
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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