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Home Biotechnologies Goldmbearing Probiotic Drug Okarin4au For Treatment Of Infectious Diseases Such As Anthrax, Rabbitmfever And Brucellosis

Goldmbearing Probiotic Drug Okarin4au For Treatment Of Infectious Diseases Such As Anthrax, Rabbitmfever And Brucellosis

Description

The deterioration of the epidemic situation in Ukraine during the last years as to tuberculosis, different hepatitis forms, infectious diseases of gastrointestinal tract, as well as constant threat of ecological disasters or terrorists attacks are stimulating the research directed to creation of new generation of more effective drugs. New type of combined probiotic drug "Okarin4Au" for prophylactic and treatment of both disbacteriosis and especially dangerous infectious diseases was developed. 3 strains of Escherichia coli and one Enterococcus faecalis strain were represented in the preparation with the ratio of 1:1:1:3.

Based on four bacterial strains taken from normoflora of gastrointestinal tract of people in good health as an active ingredient, the drug is also modified by gold in colloidal form. Our previous investigations showed that modification of initial probiotic drug by metals in colloid form variates the properties of the microorganisms' cultures, which formed the basis of preparation, and stimulates their biological activity. "Okarin4Au" preparation is available in the form of gelatinous capsules containing dried bacterial cultures bearing colloidal gold particles. This approach leads to deliverance of the whole preparation without any losses directly to the part of gastrointestinal tract which demands probiotic treatment.

Innovative Aspect and Main Advantages

Probiotic drug "Okarin$Au" has a number of prominent advantages:

  • Wide range of antagonistic activity to pathogenic organisms causing anthrax, rabbit-fever, salmonellosis, brucellosis etc. (according to results of clinical trials);
  • Selective bactericidal activity as to pathogenic microflora and simultaneous stimulation of normoflora. This feature deals with the presence of colloidal gold metals (Fig. 2);
  • Could be used for treatment of oncological patients due to high resistance of probiotic's microbial cultures to antibiotics and chematherapeutic agents. Also this drug has the ability to increase the lysis of atypical pathological cells;
  • Ability to stimulate the nonspecific immunoresistance of the whole organism;
  • Low cost in comparison with other probiotic drugs which are available on the market today.

Areas of Application

"Okarin4Au" can be used for prophylaxis and treatment of disbacteriosis of wide etiology including healing of oncological patients in the postchemotherapeutical period.


Fig. 1 The shape of goldMbearing probiotic drug "Okarin4Au"


Fig. 2 Results of the clinical testing of the bacteriological concentrate "Okarin4Au":
1 – the state of the microbiocenosis of gastrointestinal tract of children on I–III disbacteriosis stages;
2 – treatment by primary pathogenetic therapy;
3 – treatment by the same pathogenetic therapy along with the goldMbearing probiotic drug "OkarinMAu";
4 – normal state of the digestive tract: bacteria that form the normal flora of humans GIT are marked blue when the conditionally pathogenic species are marked red

Stage of Development

Laboratory prescription for production of bacteriological concentrated product "Okarin4Au" has been developed. Preparation has also passed preclinical and clinical tests (result of clinical trials are shown on Fig. 2).

Contact Details

Institute of Biocolloidal Chemistry of National Academy of Sciences of Ukraine
Contact person: Zoya Ulberg
Address: 42, Vernadskogo Av., 03142, Kyiv, Ukraine
Теl: (380 44) 424 1919;
Fax: (380 44) 424 8078
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it ; This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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