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Home Biotechnologies Method Of Production Of Spirulina Biomass With Elevated C-Phycocyanin Content To Enhance The Immune System

Method Of Production Of Spirulina Biomass With Elevated C-Phycocyanin Content To Enhance The Immune System

Description

Production of Spirulina biomass enriched with an immunomodulator c-phycocyanin administrates by the cultivation of Spirulina platensis, strain G-27. This mutant strain is able to accumulate up to 36% of phycocyanin in dried biomass while its parental strain contains no more that 15% of dried biomass. The lack of thick polysaccharide sheath on G-27 filaments and their enlarged length makes Spirulina biomass harvest and the washing easier and more effective upon the filtration through wire-gauze. It was shown that the biomass of G-27 strain is not toxic. Model experiments have shown that the feeding of the rats having experimental radiation lesion or an anemia with G-27 strain biomass led to significant correction of both pathological processes.

Innovative Aspect and Main Advantages

A mutant of Spirilina platensis with genetically determined c-phycocyanin overproduction has been obtained. This feature of mutant strain seems to be exceptionally stable during recent 15 years.

The cultivation of G-27 strain instead of its parental strain leads to the increase c-phycocyanin yield because of its higher content in biomass as well as the optimization of the cultivation conditions. The c-phycocyanin content in G-27 strain biomass exceeds that index in a prototype strain up to 1.7 - 2.9 folds under the same cultivation conditions.

G-27 strain long trichomes (fivefold longer than that of prototype strain) make the process of biomass collecting and washing by means of filtering significantly easier

.

Areas of Application

The Spirulina platensis strain G-27 with enhanced content of an immunomodulator c-phycocyanin might be used for the production of the health prophylactic food formulas and cosmetic stuff.


Fig. 1 Spirulina platensis (Nordst.) Geitl. mutant G-27 strain.


Fig. 2 Spirulina platensis (Nordst.) Geitl. wild strain (prototype).


Fig. 3 Liquid cultures of Spirulina platensis G-27 mutant
strain and wild strain (prototype):
left – mutant strain G-27,
right – wild strain.

Stage of Development

Development phase – laboratory tested

Contact Details

Odessa Mechnikov National University
Contact person: Sofia Karakis
Address: Dvoryanskaya St., 2, Odessa, Ukraine, 65026
Telephone: +38(048)7264426
Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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