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Home Biotechnologies Method Of Production Of Spirulina Biomass With Elevated C-Phycocyanin Content To Enhance The Immune System

Method Of Production Of Spirulina Biomass With Elevated C-Phycocyanin Content To Enhance The Immune System


Production of Spirulina biomass enriched with an immunomodulator c-phycocyanin administrates by the cultivation of Spirulina platensis, strain G-27. This mutant strain is able to accumulate up to 36% of phycocyanin in dried biomass while its parental strain contains no more that 15% of dried biomass. The lack of thick polysaccharide sheath on G-27 filaments and their enlarged length makes Spirulina biomass harvest and the washing easier and more effective upon the filtration through wire-gauze. It was shown that the biomass of G-27 strain is not toxic. Model experiments have shown that the feeding of the rats having experimental radiation lesion or an anemia with G-27 strain biomass led to significant correction of both pathological processes.

Innovative Aspect and Main Advantages

A mutant of Spirilina platensis with genetically determined c-phycocyanin overproduction has been obtained. This feature of mutant strain seems to be exceptionally stable during recent 15 years.

The cultivation of G-27 strain instead of its parental strain leads to the increase c-phycocyanin yield because of its higher content in biomass as well as the optimization of the cultivation conditions. The c-phycocyanin content in G-27 strain biomass exceeds that index in a prototype strain up to 1.7 - 2.9 folds under the same cultivation conditions.

G-27 strain long trichomes (fivefold longer than that of prototype strain) make the process of biomass collecting and washing by means of filtering significantly easier


Areas of Application

The Spirulina platensis strain G-27 with enhanced content of an immunomodulator c-phycocyanin might be used for the production of the health prophylactic food formulas and cosmetic stuff.

Fig. 1 Spirulina platensis (Nordst.) Geitl. mutant G-27 strain.

Fig. 2 Spirulina platensis (Nordst.) Geitl. wild strain (prototype).

Fig. 3 Liquid cultures of Spirulina platensis G-27 mutant
strain and wild strain (prototype):
left – mutant strain G-27,
right – wild strain.

Stage of Development

Development phase – laboratory tested

Contact Details

Odessa Mechnikov National University
Contact person: Sofia Karakis
Address: Dvoryanskaya St., 2, Odessa, Ukraine, 65026
Telephone: +38(048)7264426
Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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