Technologies available for licensing, investment, joint ventures and R&D contracts in Ukraine, Azerbaijan, Georgia, Moldova, Uzbekistan

Frontpage Slideshow (version 2.0.0) - Copyright © 2006-2008 by JoomlaWorks

Google Translate

Patenting Information

Tag Cloud



Free counters!

Home Biotechnologies Nanoscale Inorganic Particles Localized in Biological Tissues

Nanoscale Inorganic Particles Localized in Biological Tissues.

Main Ideas, Connected with Nanoscale Crystal Particles in Biological Tissues

  1. By means of exact physical methods it is possible to obtain new unique information about properties of nanocrystals localized in biological tissues.
  2. The new information serve for us as background for creation of new type synthetic materials, which have properties similar to properties of biological systems.
  3. On the base of the synthetic materials it is possible to create devises and goods, which will use the principles of biological tissues functioning.

Types of Nanocrystals and Studied Biological Tissues

We have studied two types of nanocrystals, localized in two types of biological tissues.

First part of our work is connected with nanocrystals of hydroxylapatite, localized in high mineralized biological tissues, such as bones and teeth.

Second part of our work is connected with nanocrystals of ferric hydroxides, localized in low mineralized biological tissues, such as brain and other tissues that contain neurons.

Applied and Fundamental Problems Connected with Our Investigations

First part of our work is connected with:

  • Development of technologies for manufacturing of synthetic analogues of bone tissue, and development of countermeasures related to phenomenon of bone demineralization during space flight.

Second part of our work is connected with:

  • Development of technologies for creation of synthetic analogues of magnetic particles localized in brain tissue.
  • Creation of systems and devices for storage and processing information, based on the principles of brain tissue functioning.

Manufacturing of Synthetic Materials for Implants, which Used for Bone Treatment

For manufacturing of effective implants, which used for treatment of bone and teeth diseases, the detailed information about internal structure and properties of bone tissue is required.


X-ray photos of human bones with implant manufactured on the base of hyroxylapatite

Most effective implant materials must to have structure and mineral phases content, similar to these characteristics of native bone tissue.

Information about Bone Properties that were Used for Manufacturing of Bone Implants

  • Hierarchy of Internal construction of bones and tooth enamel.
  • Impurity crystal phases in bone tissue and methods for registration of the phases.
  • Role of carbonate matter in functioning of bone tissue.
  • Mechanisms of assimilation processes of implanted material by living bone tissue.
  • Interaction mechanisms of mineral and organic matter in bones.
  • Methods for control of bone restoration processes at level of nanoscale subsystems of bone tissue.


Bone fibrils with nanocrystals


Nanocrystals in tooth enamel

Synthetic Material “SynBone” Manufactured for Treatment of Bone Diseases

As a result of our study, the synthetic material “SynBone” were manufactured.
The advantages of the material are connected with:

  • The mineral phase content of the material can be varied in wide interval of following components: hydroxylapatite, glass, vitlokite, vollastonite.
  • Resorbtion time of the implants can be varied from 6 month to 20 years.
  • Compression strength of the material can be varied in interval (1-600) MPa.
  • Porosity of the material can be varied in interval (5-85)%.
  • Regulation of the resorption mechanisms of the material is possible.
  • The material “SynBone” stimulate the biological reactions for restoration of bone tissue.

Example of Synthetic Material SynBone

Example of Synthetic Material SynBone

Clinical Using of the Implant Material “SynBone” for Treatment of Bones in Ukraine

The experimental and clinical approbation of the material “SynBone” is performed. The permission for using of the material in clinics of Ukraine is obtained. At present more then 300 operations in clinics of Ukraine are performed with material “SynBone”. The special technologies for manufacturing of synthetic material “SynBone”, for different clinical situations, connected with bone diseases, are developed.

Implant manufactured by computer modeling
Implant manufactured by computer modeling

Resorbed composite Implant
Resorbed composite Implant.
Penetration of bone tissue in implanted material is shown

Magnetic particles Localized in Brain Tissue

Due to biomineralization processes the magnetically ordered particles are formed in brain tissue.

The magnetic resonance spectra of the particles can be registered by technique of Electron Paramagnetic Resonance.

Two type of resonance signals caused by physiological and pathological particles are registered in brain tissue.

The signals with similar spectroscopic characteristics are registered in different tissues that include neurons: human and animal brain, spinal cord, nerve fibrils, organic matter of mollusk shells, etc.


Neuron in human brain


Human brain

Resonance Signals in Brain Tissue Caused by Magnetic Particles formed Due to Physiological and Pathological Biomineralization

Two types of resonance signals have been registered in brain tissue and other tissues that contain neurons.

  • First type have narrow lines. Line width in interval (5-6) mT.
  • Second type have broad lines. Line width (25-50)mT.

First and second types of the signals are caused by physiological and pathological particles accordingly.


Narrow signal


Broad signals

Possible Role of the Magnetic Particles in Functioning of Brain Tissue


Fig. 1




Fig. 2

On the base of temperature (Fig.1) and angular (Fig.2) dependences of resonance fields, the conclusion were made that the signals are caused by ferrimagnetic particles.

The magnetic particles are represented by ferric hydroxides [FeO(OH)], which associated with macromolecules of neurons.

We hypothesis that the physiological particles play important role in functioning of brain tissue and that the pathological particles can be a cause of brain diseases.

Anomalous Dynamical Effects, Registered by Magnetic Resonance, and Creation of Synthetic Analogues of the Particles


Coherent zones appearance


Threshold character of the effect

Physiological magnetic particles, localized in brain tissue, demonstrate the presence of unique anomalous dynamical effects, which are represented in the Figures.

If the microwave power exceed a critical value then the coherent signals have appeared on the contour of the resonance signal.

The anomalous dynamical effects can be used for control of technologies for creation of synthetic materials, which will have properties, similar to properties of magnetic inclusions in brain tissue.

Generation of Microwaves, Macroscopic Quantum Oscillations, and Creation of Devices on the Principles of Brain Tissue Functioning



New physical phenomenon connected with generation of electromagnetic waves by magnetic particles, localized in brain tissue, is discovered.

It is shown that macroscopic quantum oscillations take place in the magnetic particles localized in brain tissue.

The oscillations open possibilities for creation of the quantum computers, based on the principles of brain tissue functioning.

Areas of Application

Medicine, clinical research

Our propositions for cooperation are following:

  • Further development of technologies for manufacturing of synthetic analogues of bone tissue and clinical examination of the materials for treatment of bone diseases.
  • Creation of synthetic analogues of magnetic particles, localized in brain tissue, for development of the systems for storage and processing information based on the principles of brain tissue functioning.
  • Development of the new approaches for creation of quantum computers on the base of synthetic materials, which will have properties similar to properties of magnetic particles localized in brain tissue.
  • Further investigation of discovered by us new physical phenomenon connected with generation of electromagnetic wave by brain tissue. Search of possible technical applications of the phenomenon. E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Contact Details

Aleksandr B. Brik
Organization: Institute of Geochemistry, Mineralogy and Ore Formation, NASU.
Address: 34, prosp. Palladina, Kiev-142, 03680, Ukraine.
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it .

Comments   

 
0 #2 pumpbuddy.us 2014-10-29 18:27
It's a shame you don't have a donate button! I'd most
certainly donate to this outstanding blog! I suppose for now i'll settle for bookmarking and adding your RSS feed to my Google account.
I look forward to new updates and will talk about this blog with my Facebook
group. Chat soon!
Quote
 
 
0 #1 how to make my skin 2014-07-19 22:28
Hello, I think your site might be having browser compatibility
issues. When I look at your website in Chrome, it looks fine
but whedn opening in Internet Explorer, it has ssome overlapping.
I just wanted tto give you a quick heads up!
Other then that, excellent blog!

Take a look at myy website: how to make my skin lighter: http://www.youtube.com/watch?v=M540h0xV-wI
Quote
 

Add comment


Security code
Refresh

For additional technologies go to: http://www.stcu.int