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Home Georgian Technologies Manufacture of Biochips for Diagnosis of Viral and Bacterial Diseases

Manufacture of Biochips for Diagnosis of Viral and Bacterial Diseases

Description

Biochips are miniaturized laboratories created for simultaneous making of tens, hundreds and sometimes thousands of biochemical tests. The biochips have wide spectrum of application: from solution of pure research problems to diagnostics of a wide set of diseases and detection of bioterrorism.

Technical biochip is a number of points-markers located on a solid plate of 1cmx1cm, each of which contains DNA-sensors (oligonucleotides), constructed taking into account genetic maps of bacteria or viruses and therefore specifically recognizing them (Fig. 1.).

We aim at two kinds of low-cost biochips (at the cost of ~10 GBP) for diagnostics:
1) diseases of urogenital tract – set of TORCH – infections. TORCH (Toxoplasma Gondii, Rubella, Chlamydia trachomatis, Cytomegalovirus, Herpes virus) – infection is an abbreviation of internal infections most commonly encountered with pregnant women which are harmful for all systems and organs of a fetus; and
2) diseases of intestinal tract - ulcerative colitis (UC). It is proposed to introduce a method of early diagnostics of UC, which has no analogues, using the biochip.

Innovative Aspect and Main Advantages

The proposed product – biochip – is a complex and sensitive diagnostics method, which determines its advantage regarding price-quality, and has represented adaptation of the most expensive diagnostics technology to living conditions in new independent countries, in Georgia in particular. First of all it is adaptation of the technology having been developed in the world over the last 20 years, the results of which are expensive biochips with high compactness (at a cost of ~£1000) containing dozens of points-markers and used for research and diagnostics purposes.

The demand for the proposed products is constant and not subject to the influence of external factors (political, economic) like the demand for food and medicine products.

Areas of Application

In medicine biochips may be used for identification of pathogenic forms of bacteria and viruses able to cause epidemic and pandemic.

In agriculture usage of biochips will enable to analyze soil for the presence and absence of bacteria increasing productivity and detect presence of pathogenic organisms in stored foodstuffs. Moreover, biochips may find application in more and more widely used bioremediation from various toxic agents, which may be controlled by specially constructed biochips able to carry out both qualitative and quantitative detection of a certain set of remediation bacteria.


Fig. 1 Biochip on a quartz plate.

Stage of Development

The technology demonstration is approved for funding by the Department for Business, Enterprise and Regulatory Reform (BERR) of the United Kingdom of Great Britain and Northern Ireland.

Contact Details

Andronikashvili Institute of Physics
Adress: 6 Tamarashvili St. 0177 Tbilisi, Georgia
Contact person: Dr Nelly Sapojnikova
Tel: (+995 32) 39 8783
Fax: (+995 32) 39 1494
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it , This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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