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Home Material Sciences Silica-Based, Biologically Active Admixtures to Cryoprotection Media Aimed at Increasing Viability and Longevity of Post-Thaw Gametes in Medicine and Livestock Breeding

Silica-Based, Biologically Active Admixtures to Cryoprotection Media Aimed at Increasing Viability and Longevity of Post-Thaw Gametes in Medicine and Livestock Breeding

Description

Development of novel applications of nanostructured silica in medicine, biotechnology and environmental protection, is a primary focus at the Institute of Surface Chemistry. Fumed silica, when included in cell suspensions, demonstrates high adhesion to the cell surface. Due to interaction with certain terminal carbohydrates of cell membrane receptors, high-surface area fumed silica nanoparticles localize at select sites of the cell membrane. As a result, nanoparticles can stimulate or inhibit functional processes in living cells, depending on the silica concentration in the cell suspension. Moreover, chemical and adsorption modification of the surface of nanoparticles by biologically active molecules diversify the spectrum of possible effects of nanostructured silica. In particular, carbohydrate molecules are promising, since they are recognized by cell receptors.

Innovative Aspect and Main Advantages

  • Nanosize fumed silica, used as a carrier in proposed nano-materials, was proved to provide itself the positive biological effect with respect to reproductive cells
  • Biological effect may be optimized by variation of admixture concentration and structure of biomolecules used as modifiers of the surface
  • No necessity exist to change the composition of existing and already used cryomedia
  • Synthesized nano-materials are used as low concentra tion (less than 0.5%) admixtures to existing cell cryomedia.
  • The price of artificial insemination may be reduced essentially by reduction of spermdoze number

Areas of Application

  • Genetics of reproduction
  • Animal breeding
  • Biotechnology


Fig. 1 Longevity of bovine gametes after freezing-thawing cycle (hours):
(1) – native cell medium;
(2) – cell medium after admixture of fumed silica;
(3-8) – cell medium after admixture of fumed silica modified
by various biomolecules.

Stage of Development

New silica-based nano-materials as admixtures to existing cryo-media were synthesized and successfully tested with post thaw bovine sperm and human reproductive cells to increase their viability, longevity and level of artificial insemination. The development of new materials was realized in the framework of STCU Project # 3103.

Product was field tested on animal sperm, was experimentally tested on human gametes and is available for demonstration.

Contact Details

Institute of Surface Chemistry, National Academy of Science of Ukraine
Contact person: Galagan Natalia
Address: 17 Gen. Naumova Str., Kiev, 03164, Ukraine
Tel.: (38044) 422 9685
Fax: (38044) 424 3567
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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