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Home Moldova Technologies Internal Complexes of Copper (II) with Antibacterial and Antifungal Action

Internal Complexes of Copper (II) with Antibacterial and Antifungal Action


The invention relates to a group of new class tiosemicarbazonatilor coordination compounds of transition metals, biologically active, showing marked bactericidal and fungicidal activities against large spectrum of gram-positive and gram-negative bacteria and fungicides. The activity of compounds is much higher compared with furatsilin and nistatin used in medical practice.

Innovative Aspect and Main Advantages

Antibacterial activity is higher by 64-4166 times – for the gram-positive microorganisms, and from 2 to 297 times – for the gram-negative microorganisms, compared with furatsilin. And antifungal activity is 1,6 to 25,8 times higher compared with nistatin. The toxicity of compounds is about 8 times lower compared with furatsilin toxicity. The procedure for obtaining the compounds is simply declared, the initial substances are available, environmentally safe yield is 82%.

Areas of Application

Medicine, veterinary, pharmaceutical industry.




Fig.1. Toxicity (b), fungicidal (a) and bactericidal (c) activities of the complexes of thiosemicarbazones classes.

Stage of Development

Compounds have been tested for the antibacterial and antifungal activity in laboratory conditions. Covered by Patent of Moldova, Nr 2003.

Contact Details

State University of Medicine and Pharmacy “N.Testemitanu”
Contact person: Prof. Viorel Prisacari
Address: Bd. Stefan cel Mare 165 Chisinau МD 2004, Republic of Moldova
Tel.: (+ 373 22) 44 630; 41 782
Fax: (+373 22) 42 344
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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