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Home     Ukrainian Institutes State Scientific Control Institute of Biotechnology and Strains of Microorganisms

State Scientific Control Institute of Biotechnology and Strains of Microorganisms,
Kyiv, Ukraine

Logo of State Scientific Control Institute of Biotechnology and Strains of Microorganisms

General Information

State Scientific Control Institute of Biotechnology and Strains of Microorganisms (SSCIBSM) is a leading scientific facility within the area of development, expertise, registration testing, standardization, determine compliance of quality control of veterinary immunobiological preparations, development of regulations concerning their production, circulation and use.

The Institute was founded in 1998 on the basis of Kyiv subsidiary of State Scientific Control Institute for Veterinary Preparations and Feed Additives. For the present time the Institute numbers 80 specialists including 2 NAAS academician, 2 corresponding members NAAS, 8 Doctors of Science and 12 Ph.D's. For the present time SSCIBSM is the single veterinary biotechnology institution performing registration trials of veterinary immunobiological preparations (as of national and foreign manufacturers) and state control of their quality.

Basis of the Institute activity is development of issues of expertise, new and improvement of existing production technologies for veterinary immunobiological preparations, development of methods and means of standardization, approbation and study of biological preparations used in Ukraine, expertise,, approbation and studies of national and foreign veterinary immunobiological preparations targeting their registration in Ukraine; deposit, maintenance, storage and supply of microorganisms strains for organizations and facilities producing biological preparations for veterinary branch, veterinary laboratories and scientific educational facilities.

Facilities functioning in the Institute:

  • National Center for Strains of Microorganisms of Ukraine, At the moment Center stores and maintains the collections containing 532 strains of microorganisms, cell cultures 24 lines 12 species of animals characterized, standardized and used for maintaining strains, standardization of laboratory research and expertise VIP;
  • Immunobiological Preparation Sector of the State Pharmacological Commission of Veterinary Medicine;
  • Reference Laboratory of Office International des Epizooties (OIE) for rabies;
  • Technical committee of Standardization No149 "Veterinary Biological Preparations and Veterinary Means to Work with Them";
  • Three Universities affiliated chairs;
  • Highly qualified specialists are getting trained through postgraduate trainings for specialty 16,00.03 - veterinary microbiology, epizootology, infectious diseases, and immunology;
  • "Microbial and molecular biotechnology in agriculture" Cluster of the scientific and technological platform "Agrifood",

Issued: scientific and production monthly journal - "Veterinary Medicine of Ukraine" (together with Vetinform, LLC) bulletin "Veterinary Biotechnology" (with IBM NAAS), a professional publication the State Accreditation Committee Ministry of Education and Science, Youth and Sport of Ukraine in the fields of veterinary and agricultural science. We invite all the interested partners to mutual successful work.

Institute’s Focus

According to the Law of Ukraine "On Veterinary Medicine" the main aim activities of the Institute are:

  • Implementation of State Control, standardization and expertise of veterinary immunobiological prepara¬tions and means for veterinary medicine;
  • Cconducting scientific research to develop regulations concerning approbation of immunological veteri¬nary preparations and their means of standardization;

The main activities of the Institute are:

  • Research on the development of new and improved technologies for veterinary immunological products, methods for their control and means of standardization, development of regulations concerning their manufacturing, circulation and use;
  • Deposit of the National Center for Strains of Microorganisms and maintaining the viability of viruses, bacteria, fungi and other biological material that used for the manufacture of animal welfare and quality control, supply of microorganisms strains for organizations and facilities producing biological preparations for veterinary branch, veterinary laboratories and scientific educational facilities;
  • Study and selection strains of microorganisms for manufacturing immunobiological preparations and standardization;
  • Development of industry standard samples for quality control of biological preparations, new formulations of culture media, etc;
  • Development and implementation in practice of veterinary medicine means of standardization for microbiological research;
  • Development of veterinary immunological preparations;
  • State control over compliance with the requirements the standards, pharmacopoeia articles, technical regulations, veterinary and sanitary rules, guidelines on the use of veterinary medicine and other documents in the process of developing, testing, implementation and manufacturing, storage, transportation, sale and use of mentioned means of in enterprises institutions and organizations of all forms of ownership;
  • Study reclamations by the way of analyzing the nature of the reclamation on the points with parallel laboratory research of quality preparation that received a complaint;
  • Certification of the manufacture means of animal welfare and quality control department of veterinary immunobiological preparations;
  • Approbation and organization of the State Trials national and foreign protection of animals in order to register their in Ukraine;
  • Testing means for veterinary medicine in order to study their effectiveness and safety in order to determine whether their production / application;

Scientific developments OF SSCIBSM

Scientific novelty developments Institute staff confirmed 23 patents of Ukraine and developed and implemented in practice more than 30 DSTU harmonized with international standards.

During the last years the Institute has developed and actively introduced into the practice veterinary medicine of standardization biotechnology industries, research and industrial laboratories.

1. Sets of test strains:

  • Bacteriological quality control of culture media;
  • Identification of Listeria
  • Quality control of culture media for the cultivation of mycoplasmas and aholeplazm;
  • Differentiation of anthrax pathogen (agent) bacteriological method;
  • Biological indicators for monitoring the effectiveness of the sterilization process;
  • Quality control of disinfection by bacteriological method;
  • Testing of new disinfectants bacteriological method;
  • Determine the activity of antimicrobial preparations;
  • For quality and quantitative determination of residual amounts of antimicrobials in raw materials and products of animal origin.

2. Standardized line of cell cultures:

The collection SSCIBSM are 24 lines passages cell cultures (pigs - 4, cattle - 2, fish - 1, dogs - 2 cats - 1, rabbits - 1, mice - 2, monkeys - 4, hamsters - 2, sheep - 2, chickens - 2, people - 1), which is used for maintaining strains and standardization of laboratory research and expertise VIP

3. Standardization of serological tests:

  • National Standard of sera - "A set of sera for standardization of antigen bovine leukemia reactions in immunodiffusion";
  • Standard reference sample for the diagnosis of rabies in reaction immunofluorescence (IF) test;
  • Sample rabies industry standard (reference vaccine to assess the quality of inactivated vaccines against rabies);
  • National standard for quality assessment of tuberculin;
  • Set to detect antibodies to Newcastle disease in reaction Hemagglutination Inhibition Test (HIT);
  • A set of antigens for the diagnosis of animal salmonellosis.

4. Means for detect genetic material of infectious agents and contaminants raw materials and VIP:

  • Test system "ASF-test" for the detection of DNA of African swine fever virus polymerase chain reaction (PCR);
  • Test system "ANTHRAX-test" for the detection of bacteria of the genus Bacillus anthracis by polymerase chain reaction (PCR);
  • Test system "RABIES-test" for the detection of rabies virus RNA by reverse transcriptase polymerase chain reaction (RT-PCR);
  • Test system "HCV-test" for detecting RNA viral haemorrhagic septicemia of trout by reverse transcriptase polymerase chain reaction (RT-PCR);
  • Diagnostic set for the detection pestyvirus "PCR-PESTIVIR";
  • Test system "Chla-Test" to detect bacteria of the genus Chlamydiaceae by polymerase chain reaction;
  • Test system "Toho-test", which is designed to detect DNA toxo¬plasmosis parasite Toxoplasma gondii by polymerase chain reaction;
  • Test system "Parvo-Test" for the detection of DNA parvovirus (Canine parvovirus) by polymerase chain reaction;
  • Test system "Sal-test", which is designed to detect the DNA of bacteria genus Salmonella by polymerase chain reaction;
  • Diagnostic set for the detection of mycoplasma DNA and aholeplazm PCR - Mollicutes-test.

Our offer

  1. Conducting seminars and training on compliance with applicable requirements for the VIP circulation, their development and registration, attestation and quality control departments of enterprises of biological industry.
  2. Training on the use of etalon test-strains of microorganisms in the standardization of the microbiological studies and the assessment of food safety, quality of disinfection, etc
  3. Expertise of normative documentation for veterinary immunobiological preparations.
  4. Manufacturing attestation and departments of biological control producers VIP
  5. Manufacturing and providing standard samples for quality control VIP
  6. Checking for Quality veterinary immunological products.
  7. Development of methods for quality control of biological products and manufacturing relevant products for laboratory diagnosis.
  8. Development of methods for long-term storage of microorganisms
  9. Depositing, storage strains of microorganisms and other biological material
  10. Selection of protective environments for lyophilization (freeze-drying) microorganisms
  11. Lyophilization (freeze-drying) strains of microorganisms.
  12. Study of biological properties strains of microorganisms.
  13. Providing manufacturers VIP production, control strains of microorganisms.
  14. Providing manufacturers VIR research and education lines inoculated cell cultures.
  15. Providing enterprises producing VIR research and education facilities standardization of microbiological testing in accordance with international requirements (reference test strains of microorganisms).
  16. Manufacturing of antigens and hyper immune sera for serological studies
  17. Consultations concerning storage methods, research and identification strains of microorganisms
  18. PCR, ELISA and serological studies for the purpose of veterinary medicine, biotechnology and agriculture.
  19. Development of primers for PCR.
  20. Detection of contaminants (foreign bacteria and viruses, mycoplasma, pestivirus etc.) PCR in veterinary immunobiological preparations and biotechnology raw materials.

Contact Details

Director: Academician NAAS A.M. Golovko
Address: 30, Donetska str., Kyiv, Ukraine, 03151
Tel.: (044) 245-76-84
Fax: (044) 245-76-08
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Website: http://www.biocontrol.kiev.ua

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