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Home     Ukrainian Institutes Institute of Cell Biology of NASU

Institute of Cell Biology of NASU

Logo of Institute of Cell Biology of NASU

General Information

The Institute of Cell Biology's mission is to develop and foster a vibrant research culture for “cutting edge” basic and applied biomedical research, and for training high quality postgraduate researchers.

Institute of Cell Biology (ICB) was established in 2000 as an autonomous research institute of the National Academy of Sciences of Ukraine. Located in the central part of the Lviv region, the Institute is ideally situated for interaction with leading scientific institutions throughout Western Ukraine, as well as in the neighboring countries of Central Europe. The Institute has established itself as a major research facility at home and abroad.

In addition to primary funding from the Government of Ukraine, ICB has been very successful in attracting grants from a variety of international sources, including the STCU, INTAS, CRDF, FIRCA, NATO, National Cancer Institute (U.S.) and the Royal Swedish Academy of Sciences. The Institute has a dynamic research environment with state of the art laboratories and core facilities.

Research and Training Foci

1. Molecular, genetic and biochemical mechanisms of regulation of metabolism in yeast, and the development of new biotechnological processes and products:

(a) Genetic construction of strains overproducing:

  • Fuel – ethanol from lignocellulose wastes;
  • Vitamin B2 (riboflavin); and
  • Flavin coenzymes.

(b) Construction of yeast strains producing yeast and heterologous proteins of biomedical interest:

  • Human pro-insulin, human liver arginase;
  • Hepatitis B surface antigen (HBsAg);
  • Fungal glucose oxidase;
  • Yeast enzymes – alcohol oxidase, amine oxidase, formaldehyde dehydrogenase.

2. Molecular mechanisms of the regulation of proliferation, differentiation and apoptosis in normal and tumor cells; development of novel approaches that will affect tumor growth and monitor the effectiveness of cancer treatment. For example, diagnostic evaluation of the expression levels of novel molecular markers in human cancer (specific signaling protein ruk/cin85) and cell apoptosis.

Research at ICB encompasses a broad range of specialized disciplines, such as cell and molecular biology, microbiology, biochemistry, genetics, immunology and biotechnology. The Institute employs over 100 specialists, including 9 Doctors of Sciences and 24 Ph.D. level researchers. Over the last 5 years, ICB scientists have published 2 monographs, 183 scientific articles, including 60 articles in leading international journals, and have obtained 3 Ukrainian patents, 4 international patents from the European Patenting Agency, and 2 pending U.S. patents.

Yeast Pichia guilliermondii strain over-producing vitamin B2 (riboflavin)
Yeast Pichia guilliermondii
strain over-producing
vitamin B2 (riboflavin)

Intact cells
Intact cells

Cells treated with cytotoxic mistletoe lectin
Cells treated with cytotoxic
mistletoe lectin

Technologies for Commercialization

  • Genetically engineered vaccines against dangerous infections;
  • Immunological tests for marker proteins of malignant tumors;
  • Cell and enzyme based biosensors to measure important analytes (ethanol, methanol, glycerol, formaldehyde, lactate, and biogenic amines, such as methylamine, dimethylamine, etc.);
  • Polyclonal immune anti-sera production for the determination of species-specific proteins in biological samples in forensic medicine;
  • Molecular (DNA integrity and chromatin structure tests) and cellular systems for evaluating tumor cell response to chemotherapeutic drugs;
  • Novel, convenient and inexpensive methods for rapid detection, isolation and quantification of apoptotic cells;
  • Monoclonal antibodies against specific signaling proteins for diagnostic kits.

Contact Details

Dr. Andriy Sibirny, Director
Address: 14/16 Drahomanova St., Lviv 79005, Ukraine
Tel.: +380 322 74 0363
Fax: +380 322 72 1648
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Website: http://www.cellbiol.lviv.ua/

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