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Home Uzbekistan Technologies Biologically Active Protein from Soybean Cake

Biologically Active Protein from Soybean Cake

Description

It has been isolated sp-2 protein from soybean cake which has shown high antineoplastic activity on a number of experimental tumor cultures (Sarcoma 108, Melanoma B-16, AKATOL and AKATON) in vivo and sporadic malignant neoplasm of a human (breast cancer and endometrium cancer) in vitro by the group of scientists from the Institute of Bioorganic Chemistry AS RU.

It has been shown, that:

  • The sp-2 protein possesses low toxicity, no fatal cases among animals were observed at < 10 g/kg doze of per os introduction, therapeutic doze of introduction of the sp-2 protein is 150 mg/kg реr os and 12,5 mg/kg hypodermically;
  • The sp-2 protein inhibits cancer tissue growth by more than 60%, and at joint treatment with 5- fluorouracil by more than 80%;
  • Biological activity of the sp-2 protein on proliferation of KML mice melanoma cells in cytotoxic test using radiometric method on activation of 3Н-thymidine shows label activation suppression by 58,5%;
  • Treatment by sp-2 protein restores the expression of bcl-2 and p53 genes in a cancer tissue up to control level and restores an apoptosis induction, not rendering negative influence on highly proliferative normal tissues of an organism.

Innovative Aspect and Main Advantages

Sp-2 protein with molecular weight of 30 кDa has been isolated from soybean cake for the first time. It can be used in a form of tablets, injections and biologically active additives.

Main advantages includes:

  • Usage of secondary raw materials;
  • Purified protein is different from those receiving out of soy milk and soy concentrate;
  • Usage of inexpensive reagents;
  • No multistage purification;
  • Ecologically clean technology;
  • Sp-2 protein does not require special storage conditions (150C).

Output is 600 mg from 100 g of dry soybean cake.

Areas of Application

It can be used:

  • At treatment of oncological diseases;
  • A dietary nourishment of oncological patients;
  • For increase of efficiency and reduction of toxicity at antineoplastic treatment.

The companies potentially interested in the project are pharmaceutical companies, or the companies producing Biologically Active Additives (BAAs).


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Fig.1 Soybean cake (1), sp-2 protein (2)


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Fig. 2. Influence of sp-2 protein in a doze of 100 cg/kg on KML mice melanoma cells:
Cytotoxic effect (isles of necrotic cells) (1);
KML mice melanoma cells (control) (2)

 

Stage of Development

Laboratory tests in vivo on Sarcoma 180, Melanoma B-16, AKATOL, AKATON cultures and in vitro on breast cancer and endometrium cancer has been carried out.

The application for International patent is under execution stage.

Search for partners for further cooperation is continuing.

Contact Details

Institute of Bioorganic Chemistry
Contact persons: Ibragimov F., Beresneva Yu.
Address: 83, Mirzo Ulugbek St. 100125 Tashkent, Uzbekistan
Tel: (+998 71) 262 3540
Fax: (+998 71) 262 7063
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it , This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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